一份來自美國的研究採用了安慰劑對照、隨機、雙盲的機制方法,收集了 13 名中年、患有肥胖且已停經的婦女,每日在自己的早餐中加入了兩顆 125 mg 的 NMN 膠囊(共 250 mg)。
服用 NMN 後,參與者肌肉中因為衰老所嚴重降低的胰島素敏感性,得到了 25 % 的提升。後續的 RNA 分析中,發現竟然受試者體內有 308 種基因的表達被改變了。
雖然肌肉的胰島素敏感性提升了,不過從體重到體脂率,從血壓到血糖,從胰島素水平到糖化血紅蛋白和甘油三酯,所有與代謝衰老的指標全都沒有出現絲毫變化,也沒有對粒線體功能產生任何改變。
在《自然通訊》期刊上,這項研究採用了安慰劑對照、隨機、雙盲的機制方法,收集了 20 位 65 歲以上的健康老年男性,進行了為期 6 週或 12 週的 250 mg / 天的 NMN 添加實驗。
這項研究採用了安慰劑對照、隨機、雙盲的機制方法,實驗中收集受試者 48 人跑者為期 6 週,受試者分為四組:低劑量組(300 mg / 天)、中劑量組( 600 mg / 天 )、高劑量組(1200 mg / 天)與對照組。參與者除了每天需要口服 NMN 外,還被要求進行每週5 ~ 6 次每次 40 ~ 60 分鐘的訓練。
檢測報告的結果:
BRL(Bellow Reporting Limit;Reporting Limit 〈 1% Label Claim):低於檢測臨界(小於標簽宣稱劑量的 1%)
ND(Not Detected):完全無法檢測到
MetroBiotech 的主要候選藥物 MIB-626 是該公司表示已設計、合成和篩選出最佳治療特性的 100 多種新型 NAD+ 增強劑之一。而主要候選藥物 MIB-626 與 NMN 有關。
西元 2021年 9 月, Metrobiotech 公司(也就是辛克萊教授創立的這家)向 FDA 發信,呼籲對於所有的「 NAD+ 產品補充劑」的審核標準應該像對待 N-乙酰半胱氨酸( NAC)一樣,希望把市面上所有的 NAD+ 產品補充劑當做「藥品」管理並下架所有的 NAD+ 補充劑產品。
FDA 之前都是睜一隻眼閉一隻眼,不過從西元 2020 年 7 月開始,FDA 開始給 7 個銷售 NAC 的保健品公司發出警告信,在警告信中提到 NAC 在西元 1963 年已經被列為了藥物,根據美國聯邦食品、藥品和化妝品法案的Section 201(ff)(3)(B)(i),一個已經被列為藥物的物質無法被作為營養補充劑使用。
而在西元 2022 年 2 月發表最新研究成果顯示,研究團隊採用了隨機對照雙盲實驗,將 32 名超重或肥胖的老年受試者(55 ~ 80 歲)分為 3 組 14 天內,12 人每天服用 1 次 1000 mg 的 MIB-626;12人每天服用 2 次,每次各 1000 mg;其餘人服用安慰劑。所有受試者均無重大健康問題,也未曾服用過 NAD+ 補充劑。
結果發現,血液中 NAD 前驅物濃度大幅上升,三組受試者尿液中的 NMN 濃度沒有顯著差異,這表明口服 MIB-626 後藥物不會以 NMN 形式通過尿液排出體外。
進一步研究發現,服用 MIB-626 的受試者,尿液中 NAD+ 循環代謝產物菸酰胺(NAM)和N-甲基-2-吡啶酮-5-羧酰胺(N1-methyl-2-pyridone-5-carboxamide,2-PY)平均濃度高於對照組,暗示他們服用的 MIB-626 在體內被轉化為 NAD+ 吸收利用。
參考資料:
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